替诺福韦-富马酸阿芬烯胺[ USAN ]
Tenofovir Alafenamide fumarate
CAS: 1392275-56-7
Molecular Formula: C25H33N6O9P
替诺福韦-富马酸阿芬烯胺[ USAN ] - Names and Identifiers
替诺福韦-富马酸阿芬烯胺[ USAN ] - Physico-chemical Properties
| Molecular Formula | C25H33N6O9P |
| Molar Mass | 592.55 |
| Solubility | DMSO |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT. |
| In vivo study | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) . |
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View History
替诺福韦-富马酸阿芬烯胺[ USAN ]
N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BET-1-丙氨酸乙酯4-甲基苯磺酸盐
N-甲基丙二酸单乙酯单酰胺
依托咪酯EP杂质A
2-(2-氨基噻唑-4-基)乙酸乙酯盐酸盐
Cholesteryl 2-(2-ethoxyethoxy)ethyl carbonate
(1-苄基-4-哌秦基)甲胺
(4-羟甲基噻唑-2-基)氨基甲酸叔丁酯
4-CHLORO-3-(((5-METHYLTHIEN-2-YL)METHYL)AMINO)BENZOIC ACID
PHENYL TRIFLUOROMETHYL SULPHOXIDE
N-[[2-[[[4-(氨基亚氨基甲基)苯基]氨基]甲基]-1-甲基-1H-苯并咪唑-5-基]羰基]-N-2-吡啶基-BET-1-丙氨酸乙酯4-甲基苯磺酸盐
N-甲基丙二酸单乙酯单酰胺
依托咪酯EP杂质A
2-(2-氨基噻唑-4-基)乙酸乙酯盐酸盐
Cholesteryl 2-(2-ethoxyethoxy)ethyl carbonate
(1-苄基-4-哌秦基)甲胺
(4-羟甲基噻唑-2-基)氨基甲酸叔丁酯
4-CHLORO-3-(((5-METHYLTHIEN-2-YL)METHYL)AMINO)BENZOIC ACID
PHENYL TRIFLUOROMETHYL SULPHOXIDE